A randomized, double-blinded clinical trial, the kind considered the most rigorous type of study, it was one of the largest and longest efforts to address questions about vitamin use. The findings were to be presented Wednesday at an American Association for Cancer Research conference on cancer prevention in Anaheim, Calif. While the main reason to take a multivitamin is to prevent nutritional deficiencies, Dr. He noted that other measures are likely to protect against cancer more effectively than the daily use of multivitamins.
Gaziano said. The study was supported by the National Institutes of Health and a grant, initiated by the investigators, from the chemical company BASF. Pfizer provided the multivitamins. The sponsors did not influence the study design, data analysis or manuscript preparation, the authors said. About half of all Americans take some form of a vitamin supplement, and at least one-third take a multivitamin. But many recent vitamin studies have been disappointing, finding not only a lack of benefit but even some harm associated with large doses of certain supplements.
The dietary guidelines for Americans state that there is no evidence to support taking a multivitamin or mineral supplement to prevent chronic disease. The American Cancer Society recommends that people eat a balanced diet , but that those who take supplements choose a balanced multivitamin that contains no more than percent of the daily value of most nutrients. View all New York Times newsletters. It is also important to note that Dr. Shin's grant received the highest score out of seven applicants. Shin and his colleagues is an important milestone for scientific research at Emory University," says Michael Johns, MD, executive vice president of health affairs at Emory University and a head and neck cancer surgeon.
The four main projects are: Chemoprevention with Green Tea Polyphenon: Investigators will use a combination of green tea Polyphenon E, a chemical substance found i n plants, and Erlotinib Tarceva , a growth factor inhibitor, to prevent advanced premalignant lesions of the head and neck. Preliminary studies show that the combination of the polyphenol, extracted from green tea, and Erlotinib together inhibits growth of SCCHN both in the laboratory and in animal models. Targeting Death Receptors-Mediated Apoptosis for Head and Neck Cancers: Researchers will work to develop therapies aimed at blocking cellular pathways that allow metastatic cancer cells to proliferate.
Curcumin has shown anti-cancer activitiy in earlier studies. While its anticancer effects are limited, curcumin does exhibit an ability to induce apoptosis cell death in cancer cells without affecting healthy cells. In this project, a group of Emory researchers has modified the chemical structure of curcumin and tested its anti-cancer activity in the laboratory.
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Eventually, researchers will develop a clinical trial to test its effectiveness. Biodegradable Nanoparticle Formulated Taxol for Targeted Therapy of Head and Neck Cancer: Emory Winship and Georgia Tech investigators will work to develop a new class of biodegradable nanoparticles, which will be designed to carry the chemotherapy drug Taxol for targeted therapy of head and neck cancers. We earned this grant thanks to the exceptional science that will be conducted here; however, it's important to note that the NCI places great value on the strong commitment of support including space, recruitment, shared resources and matching funds from the Emory University School of Medicine, Emory's Woodruff Health Sciences Center, the Georgia Cancer Coalition and the Georgia Research Alliance.
This grant truly represents a team effort. About Specialized Programs of Research Excellence: SPORE grants were established in to support translational research, which are studies that apply the lessons of the laboratory to patients and, conversely, use what is learned from patients to advance study of a disease. For more information, log onto the National Cancer Institute website at www. Biomarkers are substances sometimes found in the blood, other body fluids, or tissues that measure biological processes, and in addition to genes and proteins, can be complex carbohydrate sugar structures that are attached to protein and lipid fat molecules.
Seven NCI-funded Tumor Glycome Laboratories are now searching for glycan-based biomarkers for melanoma, and breast, ovarian, lung, prostate, colon, and pancreatic cancers. Niederhuber, M. Today, with the advent of advanced technologies to conduct protein and carbohydrate chemistry, research into this intriguing area has experienced renewed interest. Glycans are extremely abundant, but recent advances in technology have only now allowed a systematic study of these structures.
Many protein biomarkers also have glycan components and analysis of these two molecular structures together may improve the value of tests such as those for prostate-specific antigen PSA , CA, and carcinoembryonic antigen, which are sometimes used in prostate, ovarian, and colon cancer detection, respectively. For breast cancer, determine how many years prior to diagnosis that progression to cancer can be predicted.
Michael Pierce, Ph. Develop assays for promising biomarkers. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical, and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases.
For more information about NIH and its programs, visit. The state is proud to announce that St. The program is designed to encourage the collaboration of private-practice medical, surgical, and radiation oncologists -- with close links to NCI research and to the network of 63 NCI-designated Cancer Centers principally based at large research universities.
Evidence from a wide range of studies suggests that cancer patients diagnosed and treated in such a setting of multi-specialty care and clinical research may live longer and have a better quality of life. The proposal brought forth by St. This information exchange from each region will provide collective experience and resources to demonstrate and provide evidence based approaches to meet the requirements of the NCCCP. Amos Cancer Center in Columbus, Georgia. The Harbin Clinic is the largest, privately-owned, multi-specialty physician clinic in the state.
It is also providing leadership in Exchange, serving as the clearinghouse for information on progress at the second demonstration site in Rome. The John B. Amos Cancer Center is a comprehensive, multi-disciplinary cancer center serving a county service area in Southwest Georgia. The Georgia Cancer Quality Information Exchange has the potential of being the first statewide evidence-based cancer quality measurement program. The national pilot will begin at eight free-standing community hospitals and six additional locations that are part of national health care systems.
An NCI panel of experts and an independent group of outside experts will set milestones, monitor progress, and evaluate success of the three-year pilot and then issue recommendations for a full-fledged program. NCCCP pilot sites will study how community hospitals nationwide could most effectively develop and implement a national database of voluntarily-provided electronic medical records accessible to cancer researchers.
The sites will also study methods of expanding and standardizing the collection of blood and tissue specimens voluntarily obtained from patients for cancer research. Underwood, president of Mercer University. This wonderful facility is the logical next step in enhancing medical education opportunities for our students.
Translational or "bench to bedside" research allows scientists and physicians to work together to quickly translate laboratory findings into new cancer treatments or prevention techniques. The facility also includes classrooms for medical students from Mercer's School of Medicine. Abrams, D. A virtual lab, said Abrams, includes medical simulations and a surgical suite for educational purposes. The multipurpose room, which bears Mercer's name, is a versatile space that can seat in theater style and in rounds.
Although most of Mercer's medical students will be involved in their clinical rotations, Abrams said there may also be opportunities for them to become involved in basic science research. Some residents are required to take part in research, so this will also offer new opportunities for them. Its presence should attract world-class clinical researchers and physicians to the area, and may also make southeast Georgia more attractive to science-based industries, such as pharmaceutical companies.
Jeff Boyd, Ph. The new facility is named in honor of Dr. Iffath Hoskins, an accomplished obstetrician for high-risk patients, and her husband, Dr. O'Regan is conducting groundbreaking work in breast cancer research, treatment and support," said Kelly Dolan, executive director of the Atlanta affiliate of the Susan G. Komen Breast Cancer Foundation.
O'Regan for the innovative and important work she is doing. O'Regan is widely published in peer-reviewed scientific journals, having published articles in journals such as Lancet Oncology, the Journal of the National Cancer Institute and the Journal of the American Medical Association. She is a member of numerous boards and scientific committees, among them the Breast Cancer Scientific Committee of the American Society of Clinical Oncology. A native of Dublin, Ireland, Dr. O'Regan earned her medical degree at University College in Dublin.
She did her U. While at Northwestern, she researched the mechanisms of selective estrogen receptor modulator or SERM resistance. Additionally, her laboratory focuses on the use of nanoparticles conjugated to antibodies to detect and quantify proteins important in breast carcinogenesis. She has developed a multidisciplinary breast cancer clinic at the Grady Cancer Center of Excellence and serves as Director of the Glenn Family Breast Cancer Fund, conducting research into the differences in molecular profiling in pre- and post-menopausal women.
O'Regan also is co-director of the Jean Sindab Project Research Team, which focuses on developing scientific research into breast cancer in African American women. The Komen Atlanta Pink Tie Ball is a formal dinner-dance to raise funds for breast cancer research, education and treatment programs. Seventy-five percent of all funds raised by the Atlanta Affiliate are awarded to local breast health projects and programs.
Twenty-five percent of the funds are given to the national Komen Research Grant Program. For more information, log on to www. Leyland-Jones comes to Emory with a vision for the future of Winship and experience in making that vision a reality. We feel strongly that Dr. I look forward to working with Dr.
The research we conduct here in Georgia will have an impact far beyond our borders. Leyland-Jones holds biochemistry, medical and doctoral degrees from the University of London. Following residency training at Hammersmith, Brompton, St. Bartholomew's and London hospitals, he completed a clinical pharmacology fellowship at Cornell University and a medical oncology fellowship at Memorial Sloan-Kettering Cancer Center. He then joined the academic staff at Memorial Sloan-Kettering Cancer Center and New York Hospitals with a special research interest in early clinical evaluation of new anti-cancer compounds.
During his time with the NCI, he was responsible for the overall development of approximately 70 anti-cancer compounds in various stages of transition from in-vitro screening to Phase III clinical trials. Our work with Georgia Tech and our research ties to the University of Georgia will continue to grow. Through collaboration with the exceptional resources we have here in Georgia, we can make significant strides in development of prevention and personalized treatment for all types of cancer. Leyland-Jones also noted the extensive community outreach partnerships and opportunities that exist in Atlanta and throughout Georgia.
Leyland-Jones led development of a clinical trials operation that integrated research with five clinical trial cooperative groups and more than 40 pharmaceutical companies. Cancer-related clinical trials at McGill currently include more than protocols at any one time and are structured through nine multidisciplinary disease sections throughout the Cancer Centre. In addition, he worked closely with the Montreal community to establish eight endowed chairs and several fellowships within the department. He has authored more than peer-reviewed articles and book contributions, abstracts and 29 patents.
Institute of Medicine April 7, Journal of Clinical Oncology January 18, Department of Defense Announcement December 2, Linden, Scott Ramsey, Nancy Anderson. Brawley, Winship Cancer Institute. Reuters Thursday, June 24, by Paul Simao. Atlanta Business Chronicle Thursday, April 22, Atlanta Business Chronicle Wednesday, April 7, Atlanta Business Chronicle Monday, April 5, Atlanta Business Chronicle Friday, April 2, Augusta Chronicle February 20, by Tom Corwin.
Augusta Chronicle January 19, by Tom Corwin. Atlanta Business Chronicle December 11, Atlanta Business Chronicle February 20, The new scholars were recruited from such nationally prestigious research institutions as Memorial Sloan-Kettering, M. The scientists are currently leading research to unlock the mysteries in such areas as molecular and cancer cell biology, cancer bioinformatics and imaging, genetic intervention and protein profiles for early detection. The IOM will develop a preliminary list of benchmarks and indicators for state cancer control success and develop benchmarks for quality indicators relative to GCC program initiatives.
IOM provides a public service independent of government agencies to ensure scientifically based and independent analysis. The GCC has incorporated outcomes measurements in its program initiatives, and has stressed the importance of performance indicators to state cancer care providers.
Initiative leaders feel strongly that benchmarks and performance measurements are a critical and dynamic process assuring that tobacco settlement dollars are used to their maximum advantage in the fight against cancer. To help assure it achieves its mission, the GCC has asked the IOM and national leaders in cancer control to recommend measures of success and to identify indicators of quality cancer care. Doing so has the potential to not only benefit residents of Georgia, but also to create a new national standard for achievement of state-wide cancer control goals.
The Georgia Comprehensive Cancer Registry is a population-based registry serving the public health needs of the citizens of the state. Supported with funding from the Centers for Disease Control and Prevention, the registry provides invaluable data to cancer researchers, program administrators, public health and the GCC. The cancer care providers of the state, the registry administrators and the Division of Public Health have done a tremendous job ensuring that we all can make data-driven decisions. With this award, the registry has been recognized for being among the best, and none of this would have occurred without the positive collaboration that the GCC has caused across the state.
A reception and poster session highlighting new cancer research and Georgia Cancer Coalition Distinguished Scholars will be held the evening of Monday, September. The Symposium will take place Tuesday, September. The Symposium will be held in conjunction with the dedication of the new Winship Cancer Institute building, which will take place on September 24, The Emory University School of Medicine designates this educational activity for a maximum of 8.
In addition, 8. Floyd, 62, of Graniteville, who is being treated for endometrial cancer at Medical College of Georgia Hospital and Clinics. Cancer networks centered around Albany and Savannah also received regional program designations. The announcements cap a two-year battle by Augusta leaders to get recognition and funding to improve treatment and research. The cancer coalition will receive another round of applications May 30 and will decide on funding afterward, hopefully in June, said Vice President Nancy Paris.
The programs have not been told how much funding might be available because "we have some and we're hoping to assemble more," including grants from private foundations, Ms. Paris said. The coalition is funded primarily by part of the state's tobacco settlement money. Still, "we're off and running," said Dr. The program is a vast, sprawling project that includes 29 hospitals and nearly 3, physicians from Augusta, Athens and 27 surrounding counties, many of them rural and underserved.
The regional programs have been long-sought symbols of civic pride for Georgia's second-tier cities since Emory University and Grady Memorial Hospital in Atlanta landed the first one in Augusta and Savannah community leaders, in particular, have jockeyed for two years to come up with proposals that would make them the next designee. Rahn said.
Coalition information More information about the Southwest Georgia Cancer Coalition, including programs being offered and how to donate money, can be found on the organization's Web site at www. The regional cancer-fighting alliance learned Thursday afternoon it will become one of the state's regional programs of excellence. They should be very excited this designation is in this area.
Officials at the state coalition had been waiting on the "green light" from Gov. The Southeast Georgia Cancer Alliance, representing the Savannah area, and the East Georgia Cancer Network, which represents the Augusta-Athens area, also received regional program of excellence designations.
All three designees rated a score of excellent from a member committee composed mostly of nationally recognized cancer experts. The provisional status of the designation is expected to be removed after the schools address a few items in their proposal, Toal said in a written statement. The governor also issued a statement, saying: "These designation awards recognize the considerable effort of cancer caregivers, patients and survivors in more than half the state's counties who have joined together to combat this dread disease in the broadest manner possible.
I salute their dedication and partnership with the state's coalition. How much funding the coalition will receive as a regional program of excellence won't be known until the end of June. The coalition's goal is to increase cancer awareness so residents will lead healthier lives and get more cancer screenings. That will help doctors catch cancer in the early stages, making it cheaper to treat and increasing patients' chances of survival. Also helping in the fight will be area patients' improved access to clinical trials of cutting-edge cancer drugs.
The designation will help snare scientists and researchers, biotech firms, and others to increase the area's knowledge and economic base, Hooks said. Five additional coalitions are vying for designations. An announcement on those applications is expected in late June. The Georgia Cancer Coalition was created in and is funded by a mix of public and private sources, including money from the state's settlement with tobacco companies. The coalition's aim is to create a statewide network of cancer care to ensure all Georgians have access to high-quality treatment close to home. Cassandra Corcoran can be reached at The Savannah News May 16, by Lanie Lippincott Peterson After more than two years of work, a county coalition of cancer survivors, doctors and educators won the designation of "regional program of excellence" from the state-wide Georgia Cancer Coalition.
That new title means the group, the Southeast Georgia Cancer Alliance, has backing from the state's top cancer officials and from Gov. Sonny Perdue in its broad-based effort to fight cancer. Alliance programs -- from new prostate cancer screenings to more clinical trials -- are expected to serve more than , people in a region that ranges from rural Coffee County to urban Chatham and Effingham counties. The Georgia Cancer Coalition also named two other groups, one in Albany and another in Augusta, as "regional programs of excellence. In a prepared statement, Purdue applauded the three groups.
He called regional cancer programs "a cornerstone of our initiative to reduce the incidence and mortality rates of cancer in Georgia. Regional cancer rates for lung, prostate and cervical cancer are higher than state-wide, Alliance figures showed. Alliance members were ecstatic that their program got state approval. There's treatment out there that just needs funding.
And clinical trials that need more people to get in. William J. Hoskins, called the new designation "great for our region. Even with a small portion of the money, "I think the organization itself is so well established, we're going to have some impact" on cancer care this year, said Hoskins, who also directs Memorial Health's Anderson Cancer Institute.
Paul P. Hinchey, president and chief executive officer of St. Most Alliance programs aren't expected to start for several months but already, Hinchey said new education programs on recognizing prostate and skin cancer are planned throughout southeast Georgia. Technicians are also being trained to open the region's first tissue bank, a depository for cancerous samples that could let researchers type cancers and seek drugs that target them. The other five, and a sixth group that received a similar grant in December, are expected to submit their applications by the cancer coalition's second deadline on May 30, she said.
The first deadline was Monday. The Augusta-based group consists of a partnership formed by the Medical College of Georgia and the University of Georgia. The Southeast Georgia Cancer Alliance includes hospitals, health districts, universities and community agencies centered in the Savannah, Brunswick and Waycross areas. The third regional coalition to file an application Friday includes health-care facilities in Albany, Valdosta and Thomasville.
Regional programs of excellence will focus on a variety of approaches to fighting cancer, including prevention, diagnosis, treatment and clinical research. However, they will not be involved in the "pure" research that the presence of research universities makes possible. The first cancer center authorized under the state initiative begun by former Gov. Coalition Executive Director Russ Toal has said he expects several cities to apply to join Atlanta as a cancer center, but Ms.
Funded by the U. Department of Defense, the program will work on identifying new therapeutic targets for advanced prostate cancer. It is led by Dr. Jonathan Simons, Winship director, and Dr. Leland Chung, an Emory urologist. Prostate cancer is one of the main focuses at Winship as it applies for prestigious National Cancer Institute status as part of the Georgia Cancer Coalition, a state effort using tobacco settlements funds to improve cancer care.
At the new Grady Cancer Center, large windows bring in natural light for chemotherapy patients who must sit long hours for treatment. A garden with a bubbling fountain relieves stress and anxiety. Advanced imaging machines can detect new cancer cases. Her plea: 'Get Help' Patient's legacy echoes as Grady opens new doors Johns for the Health Sciences Center. But no one at Emory felt this more deeply than Dr. Chung headed one of the 80 scientific experiments aboard the shuttle. He and colleagues at the Fred-Hutchinson Cancer Institute in Seattle and the University of Virginia were trying to use the zero gravity environment of space to learn more about how prostate cancer cells grow in bone, something of special interest since many advanced cases of prostate cancer metastasize to bone.
While doing this, Dr. Chung worked closely with NASA engineers and the astronauts on the mission. Data had been arriving back from the experiment - which was going extremely well, producing dramatic results - and on Saturday Dr. Chung was happily awaiting the astronaut scientists' return to earth. He was stunned, needless to say.
Speaking of the lost astronauts, he told the Atlanta Journal Constitution that it felt "as if they were our partners. Fray Marshall, chair of the Department of Urology, talked to numerous reporters on Dr. Chung's behalf. He expressed the deep sadness everyone at Emory involved with the NASA team was feeling but also the "fervent hope that the exploration of space and our exploration of the solution to cancer is not slowed with this national tragedy.
Chung is continuing his research and plans to validate the information obtained from the experiment to develop better prevention and treatment strategies for prostate cancer. He also wrote NASA to say "We want to dedicate every paper we publish on this series of study to our partner astronauts.
We will move this forward with new nergy and dedication. May God bless America. Our dreams of discovery and innovation will always include a piece of our NASA family. Chung himself: "Discovery for tomorrow should not stop today.
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Johns says, "Tragedies like the loss of the Columbia remind us of how fragile life is, but perhaps even more importantly of how heroic is the human spirit. Our hearts go out to the families and colleagues of those who died, and we take this moment to both mourn them and to celebrate their dedication to science -- the same dedication so many of you show every day. Roy Barnes in with the aim of making the state a national hub for cancer research and treatments.
The allocation would match last year's. Perdue is expected to meet with leaders of the GCC in the coming weeks to discuss his plans for the organization in greater detail, according to a statement released today by GCC President Russ Toal. Toal said the GCC is pleased with Perdue's plans to devote two-thirds of the state's tobacco settlement payments to health care, including cancer initiatives.
The GCC also stands behind the governor's plans to raise the tax on tobacco, he said. Augusta Chronicle, January 23, Gov. The governor went to the hospital Wednesday in his first official trip to the city. Raising taxes would be a last resort, but Gov. Sonny Perdue said he will not gut education, health care and child welfare to avoid it. And there could be a health argument as well as an economic advantage to raising the cigarette and liquor taxes, he said. Perdue, who earlier took part in the groundbreaking for the Paul D. The funding mechanism for the Georgia Cancer Coalition - two-thirds of the state's share of the tobacco settlement money - will remain the same despite the tight budget, Mr.
Perdue said. Toal said. The governor's budget proposals to raise those taxes and reduce the property tax exemption have met with little public enthusiasm and have encouraged efforts to cut spending. MCG President Dr. Daniel Rahn center talks in a hallway with Mr. Perdue right and the governor's assistant Chris Young during the governor's tour through the children's hospital.
Randy Hall, R-Augusta. I don't see any significant pullback in that at all. Perdue said that he has urged his department heads to continue looking for cuts but that there might not be enough in the budget. We cannot find the money at this point without affecting education, health care, Medicaid and protection of children. Aside from the revenue aspect, there's a health aspect to the excise tax on tobacco and on alcohol, to some degree, with DUIs and traffic deaths and family violence associated with the use of alcohol," Mr.
Frankly, I look at it as trying to save their lives. David Wahlberg - Staff Saturday, January 11, An Emory University scientist is sending a prostate cancer tumor into orbit aboard space shuttle Columbia, scheduled to launch next week. Urologist Leland Chung's celestial research has a down-to-earth goal: to study tumors in a three-dimensional, gravity-free setting that better resembles cancer in the human body than cancer grown as a thin layer of goo in petri dishes.
If the NASA-sponsored journey set to begin Thursday proves instructive, "in the future we may do early drug trials at the international space station before we conduct them in humans," Chung said. For years, researchers have struggled to come up with 3-D clusters of cancer cells in the lab that mimic the look and activity of actual tumors.
Some have placed cells on collagen scaffolds, but they can contain foreign material that throws off results. NASA scientists, inspired by a technician who spun a syringe in an electric drill for kicks, invented a rotating "bioreactor" that keeps tissue suspended in a state of extremely low gravity. Chung has been using bioreactors to study prostate tumors and their interaction with bone cells since Now his samples will ride inside a bioreactor on the shuttle, where near zero-gravity conditions should allow tumors to grow even more purely, he said. Ovarian, skin and colon cancer cells traveled on the shuttle Discovery in August, but this will be prostate cancer's space-travel debut.
NASA routinely invites scientists to conduct experiments on shuttle flights. Chung hopes to see what happens when the cancer cells grow into bone, a process known as metastasis, which could lead to better diagnostic tests. But the main purpose is to compare how tumors grow in space to what is known about how they grow inside the body. That will help determine how useful the low-gravity cancer model will be for future research, since humans won't be shedding their gravity anytime soon.
The grant and other in-kind and financial contributions are being used to to support the regional group's work on a final proposal for continuing funding to become a Center of Excellence under the state organization. Regional groups' applications for regional programs of excellence must be filed with the state organization by March 7. Awards are to be made by May 1. The outgoing steering committee elected the directors, who will meet in February and elect officers. Steve Johnson, Archbold Memorial; Dr.
Kimberly Redding, medical director of the state's cancer control office. Reaching doctors with the message that every woman older than 40 needs to get a mammogram yearly for breast cancer, and that all women need regular Pap tests for cervical cancer, is also part of the strategy, said Russ Toal, GCC president. More than 80 percent of the women polled reported they had regular breast and cervical cancer screening, Redding said.
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Other reasons given by those who didn't get checked included having no health insurance; relying on their physician or nurse practitioner to tell them they needed Pap tests or mammograms; and believing that they weren't at risk for cancer. Regular checkups help doctors discover cancers earlier, before the disease has spread and becomes harder to treat. Breast and cervical cancer are the first of five cancers being tackled.
The survey of Schapiro Research Group used more than 1, interviews taken from 27, random phone calls in all Georgia counties. The cancer coalition was launched two years ago by outgoing Gov. Roy Barnes with the aim of reducing cancer mortality, improving services to minority and rural residents and increasing cancer research. Graphic For cancer screening, women are urged to contact their health care provider or county health office. For more information or referrals, call or visit the Web site www.
In a matter of weeks, the much-anticipated Georgia cancer initiative will finally open up shop for patients. Two renovated floors at the state's largest public hospital, Grady Memorial in downtown Atlanta, will house the Georgia Cancer Center, the first tangible accomplishment of an initiative announced in May by Gov. Roy Barnes. Even with his defeat by Republican Sonny Perdue, the cancer crusade will continue, local health care providers and politicians said. Coalition President Russ Toal told a meeting of cancer doctors Wednesday night that he expected the program to survive Mr.
Barnes, said Stephen Peiper, the chairman of pathology at the Medical College of Georgia, who attended the meeting. Toal said the cancer program had received bipartisan support for its funding requests and that Mr. Perdue had agreed in the gubernatorial debates that it was a strength for the state, Dr. Peiper said. No," Dr. But it was his expectation that the process would continue. Defeated Senate Majority Leader Charles Walker had all but promised that Augusta would get one of the top-tier centers. Georgia Sen.
Don Cheeks, D-Augusta, said Thursday that he would be willing to switch parties, and possibly give Republicans control of the state Legislature, upon Mr. Perdue's promise that Augusta would get such a center. Barnes and Mr. Walker toward a cancer research center at MCG. That funding is part of what Mr.
Cheeks would be seeking. Cheeks said. Read said. Staff Writer Heidi Coryell Williams contributed to this report. Reach Tom Corwin at or tomc augustachronicle. Locally, incumbent state Sen. Perdue was unavailable for comment Wednesday. The coalition fosters partnerships between business and medical communities to combine resources in the battle against cancer. More money is expected to follow, especially if a region is designated a cancer center of excellence.
This is a great thing for all of Georgia. The funding will expand the prostate cancer professional education and awareness effort, support the development of a colorectal cancer screening plan, expand the Breast and Cervical Cancer Program and maintain support for the Cancer Registry and the Comprehensive Cancer Control Program.
The tiny particles glow and act as markers on cells and genes, giving scientists the ability to rapidly analyze biopsy tissue from cancer patients so that doctors can provide the most effective therapy available. Toal, consultant Kathy Russell and Dr. The county Northwest Georgia coalition is one of eight regional groups that were awarded planning grants to develop applications in hopes of being designated a Regional Program of Excellence.
The regional designation is the first step in possibly being named a Center of Excellence, which recognizes programs that have significant sustained research and educational background. This program will allow nurses and nursing students to take a specific oncology nursing course of study over the Internet and at community clinical sites. There is a shortage in this field and this third year will allow students to become more thoroughly trained for careers in radiation therapy.
This pilot initiative will be used as a model for other industries throughout the region. The Rome visit is the first of eight site visits the Georgia Cancer Coalition is conducting across the state with regions that received planning grants in June. The coalition will be evaluating the progress being made in each region, as well as the types of programs being developed.
The state coalition will then offer suggestions and comments as to the direction the regional coalitions are taking. What if a friend had simply explained how to do a breast exam? What if there had been health insurance? A paycheck? A car? She often returned by bus because of heat and her fatigue. Black men in Georgia die from prostate cancer at a rate 2.
To address the disparities, the state has mounted the Georgia Cancer Coalition, a year effort to bring top researchers and new treatments to the area and boost cancer screening and prevention efforts. Sits, stares and spins through a familiar list of what if, what if? Everyday life grinds on below her small apartment balcony overlooking North Avenue. Honking cars. Sputtering buses. Bits of breezing-by conversation. It's a perfect sunny Atlanta day, but not one she can truly enjoy. The reason is etched in X-marks on a wall calendar in her living room.
On every month since December, the 17th day has been crossed out with a pen. How many more months? How many more calendars? It's death," Rebecca Simpson says, still reeling from the breast cancer diagnosis that changed her life last year. You just think you're dying when they tell you it's cancer. But on the 17th of every month, the day of my surgery, I thank God I'm still alive.
She can't guess what might have occurred if so many things had been so different: her bank account, her health care, maybe even the color of her skin. All she knows for sure is what it says on her medical file: African-American female, 61, breast cancer. And because the tumor had spread to her lymph nodes and was discovered late, she must live with the knowledge that the odds aren't as good as they would have been had the cancer been caught in its earliest stages, when it's 96 percent curable.
But since no one in my family ever had cancer, I didn't think about it. I thought I was exempt. On February 17, , I again went to sleep believing I was on the way to healing. Instead, I woke up to learn that the cancer was more aggressive than initially thought and there was a potential I would be returning for a third surgery.
I spent the next week trying to recover in the hospital and was on the verge of dehydration and malnutrition. My recovery was very difficult, and only made my battle that much harder. A six-week bed rest followed as my journey back to a healthy recovery began. Six five-hour cycles of very aggressive chemotherapy, which included a cocktail of Taxol and Carboplatin as well as intermittent injections of Neupogen and Epogen, killed the bad and the good.
I was left week, exhausted, and many times sick. It was an "outer body experience" that kept me fighting. And again, I am taking oral contraceptives -- a known preventative of ovarian cancer. I am now "cancer free" and have been since September 9, Throughout my ordeal, I continued to teach aerobics and began working full-time in July of I have since taken my tragedy and turned it into something positive.
On June 7, I established R. Research for Ovarian Cancer and Continued Survival. It is a non-profit tax-exempt charity dedicated to educating women about ovarian cancer and raising money for education and public awareness. In addition, I was interviewed by a Connecticut hometown newspaper, which was subsequently featured in several other town papers in that region. I also was asked to share my story with pharmaceutical sales representatives of Smithkline Beechum in November I continue to tell my story as an avenue for getting awareness about ovarian cancer into the public.
The organization has produced and distributed information pamphlets about R. That interview was read by producers of the Lifetime TV show Speaking of Women's Health and provided me with another opportunity to speak publicly about ovarian cancer. It will be aired on Saturday, November 2nd The interview was re-broadcast on the news the following morning.
I learned I was pregnant. Unfortunately, the being growing inside of me lost its life after 3 months. I hope that we will soon be able to have another miracle of life for all those who have suffered, survived, and past away from this horrid disease. After nearly four years of being cancer-free, I am looking at my options to determine if I am having a recurrence and the possibility of losing my fertility. It's a battle I sadly must continue to fight. My motto is as follows: For every battle, there is an ending.
For every ending, there is a beginning. For every beginning, there is success. When we have success, this battle will end. It is with the hopes of my story that no other woman will have to suffer like I have. And that with the help of volunteers, friends and family members, my motto will be achieved. Amy's grandmother My grandmother was diagnosed with ovarian cancer on August 3, The doctor estimated how long my grandmother had to live, but little did he know my grandmother was a very strong woman. She was given 1 year to live without chemotherapy, with chemotherapy, she was given 5 years.
My grandmother made the choice of losing her hair and feeling sick one day out of every week while taking chemotherapy. After a while my grandmother started to feel sick every day, no matter what. She called the doctor to see if he could figure out what was happening, and he told her to have a CAT scan done. When she had the CAT scan done, the doctor told her that the cancer had spread to her colon and spleen. After a great deal of thinking, my grandmother decided to have her spleen and half of her colon removed. Finally the cancer had metastasized throughout her whole body, and she died on October 10, Andrea King Collier Although it has been 10 years since my mother died of ovarian cancer, the illness impacts me every day.
I am ever fearful that genetics and heredity may bring ovarian cancer my way. I worry that there is no really accurate early detection out there for me and women like me. But I am grateful for and encouraged by the women who are living-yes living with ovarian cancer and defying the odds. They are heroes and champions and poster girls for those of us who are fearful. I have met so many wonderful women who are fighting and making a difference since I wrote my book, Still With Me, on my mother's battle with ovarian cancer.
I think I am doing what I do now because I need to be my mother's voice in this fight that we are all in. I just hope that all of the dear women who are living and thriving and fighting know that they give are the standard bearers for the rest of us, who hope and pray and advocate and believe. I see my mother's eyes in yours. Thank you. My husband, two children and I were so excited. We couldn't wait until we held our new baby in our arms and looked forward to sharing our lives together. As a family, we enjoyed many walking trips, but one will always remain in my mind It was a beautiful summer day.
I was 7 weeks pregnant. We had decided to go on a walking trip and as we were having so much fun, the day passed by quickly. After arriving home and trying to wind down for the day, I felt a little discomfort and realized I was spotting. Of course I panicked as you can only imagine the thoughts I was having.
I began to pray for my baby. My intuition told me something was wrong. Upon contacting the hospital, they requested I wait until the morning and to keep watch over how I felt through the night. For some reason, one that I cannot explain, I continued to have a bad feeling about what was happening. Most of the night was spent worrying about my baby, and as the spotting continued, I headed to the hospital. Once arriving at the hospital, I had an ultrasound performed. The doctor said the spotting was due to a little clot underneath my uterus and that I shouldn't worry as it would soon dissolve.
He then sat down, and told me that there was another problem. As he cleared his throat, he asked me if I was aware that I had a large cyst in my left ovary. The shock was devastating. I wasn't sure what he was telling me exactly. All I know is that I had the longest drive home. On the following day, I visited my doctor. She didn't exactly know what to say to me, but the look on her face told me she too was worried. Before finding out from him what I was so afraid to hear, I explained to the doctor all my fears. I told him that I loved my baby. I told him that I didn't want to lose my baby.
I cried and cried. I needed him to understand that I was so very afraid of what I expected he was going to tell me. He touched my hand and said that he thought I had ovarian cancer. The room began to spin. He had to have been wrong! I am a young and healthy mother. My uncontollable tears flowed. How could this happen to me?
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How did this happen to me? The doctor then told me something that no pregnant mother would want to hear. He said that I would need to have surgery to have the tumour removed. The surgery would have to be performed on my 20th week of pregnancy, as this was the safest time for the baby to successfully recover from any trauma. I prayed to God for his guidance, support and to help me make the right decision. The world so often felt like it wasn't there. All that mattered to me was my family. I wanted to have a healthy baby. I wanted to be here for a long time. I couldn't imagine my children without me.
I wanted to see them grow up, get married and have their own families. I wanted to fulfill all my dreams. I was too young to die. My baby needed a chance to live. I prayed every moment I was awake. My faith in God became stronger each day. I knew in my heart that no matter what happened, God would take care of me.
My husband held me and explained to me that he wanted me to have the surgery as our other two children needed a mommy. I knew the ultimate decision was mine. The decision to have my ovary removed while pregnant would risk my baby's life. If I remained pregnant after the surgery, my child could have ended up with many serious problems. The love for my unborn child was stronger than I could ever explain, as I knew my baby's fate was in my hands. The confusion was overwhelming.
From weeks of crying, I looked awful and many around me were worried for my health. The time had come to make my decision. In my heart I knew that God was right by my side. He said to me, that if I was his wife and we already had two children, that he would want me to have the surgery. He said that God gave me two healthy children to take care of and it was my responsibility to be there for them.
As he did not know how quickly the tumor was progressing, the cancer could be at its worst stage at time of delivery of my baby. If I waited until my third baby was born to have the surgery, my husband may be taking care of 3 children on his own. God gave me the strength that day, for I decided that this silent killer, which is what ovarian cancer is really called, was not going to beat me.
I decided to have the surgery. While recovering from the devastating experience, my baby's heart beat dropped very low. I cried and prayed. I couldn't lose her, not now, not ever. My faith in God and my many prayers is what got me throughout the next several months. My beautiful angel was born by C-section at full term.
She is now 5 years old, healthy, happy and so very special to me. My dear daughter and I have a bond that I could never explain to anyone. I risked her life to save mine and I must always remember how much I prayed for her. I believe in my heart she was and still is my guardian angel. If I wasn't pregnant with her, I would never have known about having cancer and maybe it would have been too late. My daughter is a gift from God and each day I thank Him for my beautiful child and for my treasured life. Each day is a gift, a true gift from God.
I am 13 years old. I have a sister who is 16 and my dad. My mother just passed away of ovarian cancer. She survived for two years. They say it is the best cancer care anywhere. Well I think it was because the doctors at the hospital gave her two more years to live. And I am very grateful for that. It was very hard leaving school to go to the hospital every so often.
All I tried to do in life was to please her but it was pretty hard when she was on antibiotics and all these medicines that made her drowsy. The last few days of her life I did not go to school. I was in the hospital with my mother. She had her eyes rolled in the back of her head, Breathing heavily, and she looked very scary. It was hard to believe that she was actually my mother. That's not a lot but if that's all I get that's good enough.
We learned about her dying two days before she did go. At the age of 21 I had to have a hysterectomy in In they had to go and get both ovaries. Well in I started having pain againg so my husband rushed me to emergency room because I could not walk. They did xrays and an ultrasound to find out my right ovary had grown back this can't be we thought the doctor just didn't take it out. So I had to have surgery to remove that one and I was feeling fine for about a year. In I started having the very same pains would not go to the doctor this time until I was unable to walk again.
We went to the doctor and was told my right ovary was back I was sent to a specialist where I had to have another surgery that year. Well it's been two years today since my last surgery but I've always been in pain and I know the ovary was removed I was in surgery 8 hours. But I'm very upset because my left ovary is back now and all doctor are refusing to help me every doctor is trying to put me off on the next.
No one is thinking about the pain I'm in how I'm unable to have a normal life with my family because the doctors keep me on strong meds that keep me sleepy. I'm looking for someone who has or had this same problem. The doctors say that it is normal but they can never tell me of another case that they have treated. I just would like some information on how we can keep this from coming back again if it's removed this year. Please anyone that can help email me at angeb34 hotmail.
I am thanking you in advance. Angela and Felicia's Mom Hi my name is Angela. And I would like to share my story. My mom was diagnosed with OVCA last year It just all happend at once. We were preparing to go to our family reunion and my mom became very ill. She was vomiting and she had a bad case of diarrhea so she was taken to the doctor.
The doctor stated that her uterus wall had fallen and he need to pull it up. Upon going to the hopital, she was still nauseated and feeling extremely bad. Then the doctor said she had the signs of gallstones. A test was ran and sure enough she did need the gallstone surgery. The surgery was done and very successful. They removed gallstones and the gall bladder. Upon removing the stones and bladder the doctor notice a lot of water. They removed about 2 pints of water from her adominal. The doctor then had the water tested, which showed positive for OVCA. My mom was 72 years old at the time.
As I write this now, my mom is in the hospital and has been there for almost 3 weeks. The chemo that she was on for the first year her body started rejecting it. She was later put on Doxil. This chemo was too strong for her and her body was not able to handle it. While doing Doxil my mom became very dehydrated and nauseated. She could not hold anything down. Her doctor recommend that she be put in the hopital so he can run test to find out what was going on. Several test have been ran and he still cannot find out what is causing this.
Right now my mom is hooked up to alot of iv's, she has swollen feet, and she is still continuing her chemo treatments. My mom is a strong woman and she is fighting hard. But through all of this I can truly say God is good.
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Prayer also changes things. About 2 days ago my mom start back eating just a little at a time but the food is now staying down!!!! She lost a tremendous amount of weight. Her feet are still swollen. She also has to do physical therapy while she is in the hospital. I hope one day they find a cure for this silent killer. This does not only affect the person with the disease but family members as well.
I just want to say to everyone who is dealing with this or any other type of cancer. They found cancer cells around her lungs in the fluid, and she looks like she is about 9 months pregnant. The doctors all have a positive attitude, but I'm still not sure how she's going to do. She just had a bypass surgery on her heart October of last year 05 because of shortness of breath She is 49 years old and has been through chemotherapy once in for breast cancer. She's a survivor of 11 years for that.
A very strong and religious mother of four wonderful children and four grandchildren, newest is now 10 months old. With her first treatment being last week she's very, very tired and suffering from depression and anxiety. I'm really worried about her and I know all there is to do is to be very supportive and to pray very hard. They are going to give her 6 chemo treatments first one every three weeks , then check the tumor s and then if necessary debulk or resume 6 more treatments. She's had so much abdominal ascites; they say surgery would be nearly impossible at this point anyhow.
Chemotherapy should dry some of it up. If anyone has had similiar stories I really want to hear about them. I would like to know things to expect and also someone to relate to. Please E-mail me at angie yahoo. Thank You, Angela B. Anita Choudhary My wife Anita initially diagnosed a case of ovarian cyst and further investigation clarified it ovarian tumor in Sep First six cycles of chemotherapy shown a lot of improvement.
But it re-occurred after three months. Again six cycles of chemotherapy were administered and transplantation of chemo pot was also done as the nerves of my wife grew weaker. This time again lot of improvement seen. But the decease re-appeared again and this time with metastasis stage. Doctors again recommeded six cycles of chemotherapy.
First 12 cycles of chemotherapy were tolerated by her well and thereafter she suffered lot post chemotherapy problems like sever body pain, vomiting, fever, loose motion etc. However, this bold lady faced all the troubles with great courage and bravery. She died after two days of 18th cycle of chemotherapy. One day before her death, two very big boils with untolerable sever pain appear on her buttock and one boil appeared on her forehead a couple of hours before she died.
Again six cycles of chemotherapy were administered on her with radiotherapy for 21 days and the result was the same This time again chemotherapy was given for six times which again brought down the AFP level below After 18th cycle of chemotherapy between 23 Sep 07 to 25 Sep 07, she died on 01 Oct I appreciate the way she fought the disease for almost two years. Despite knowing the fact of her end, she always motivated the inmates while in hospital. Ann Cassidy My mom was diagnosed with ovarian cancer on September 17, after going to the hospital with severe abdominal pain.
We were told by her physician that her condition was serious and that we should consider treatment at a different facility. My mom had an extremely high tolerance for pain she had 7 kids without any type of pain medication. She was always afraid of being over medicated and not lucid. I want people to know that it is so important to be at a facility whose sole purpose is treatment of cancer patients.
After arriving at Sloan Kettering we felt a glimmer of hope that she would be with us for a few years at the very least. On September 25, we were told that her cancer was inoperable at this time and that chemotherapy was her best bet. My mom was a slender woman except for her mid-section which she blamed on having so many kids and we believed her. I believe that you can will your mind to do certain things and my mom wanted to see her baby get married in July After a few days at Sloan her condition seemed to improve and then just like that she was declining rapidly.
She was never alone and time seemed to be moving slowly; I never knew what day it was I just wanted to be there. We all did. On October 15, we received the news that she would not be able to handle any type of chemo treatment and that she could go home or to a hospice.
She came home on October 20, and amazingly we were able to take care of her. All our lives were on hold nothing seemed to matter except to be with her and comfort her to the best of our abilities. On the night she died her children, grandchildren, her sister and my dad were at the house. The grandchildren she adored came in to see her; they loved her so much. My mom died on October 25, at home with her family. Thirty-nine days 39 and she was gone.
My mom did go to regular checkups with all kinds of doctors except she had not gone for a gynecologist visit since Pawelski, husband Introduction: This is an account of my wife's treatment for recurring ovarian cancer. Her cancer treatment varied tremendously depending on which hospital she attended and the type of treatments given at our local hospital were responsible for her final tumor recurrences and her depressed quality of life in her last years.
When she first got ovarian cancer in , it was treated in San Diego, post-operatively with Chlorambucil. This is one of the slowest acting and least toxic of the oral drugs, which allows the immune system to regenerate during the process. The cancer recurred in on her diaphragm and was removed at the Fox Chase Cancer Center. It is commonplace to give the same treatment to a recurrence as was given for the original tumor s.
However, our hometown hospital in Pennsylvania gave her a 'hard and fast' drug combination of Taxol and Carboplatin. This suppresses the immune system, which can allow tumors to grow and can weaken the blood-brain barrier, potentially inviting cancer cells into the central nervous system.
Sure enough, the cancer turned up in her cerebellum in , and was removed at the Hershey Medical Center. Our local home town hospital then treated her with Whole Brain Radiation. My wife was Hershey suggested treatment with focal radiation to the local tumor bed. Scans to check for a possible spinal tumor were also suggested but never fully carried out. In , three tumors were found on her spine and were eradicated. In the end, my wife died of the effects of Taxol and Carboplatin, which may have caused the cerebellum tumors, and the terrible effects of Whole Brain Radiation, which further scans revealed had caused extensive damage to her brain.
Ann's Medical History: In , my wife had been diagnosed with ovarian cancer, when she presented with a left DVT deep vein thrombosis and pulmonary embolism at a hospital in San Diego, CA. DVT is not uncommon in patients with ovarian cancer it may be a presenting sign. Workup which was triggered by this presentation revealed that she did have an ovarian carcinoma for which she was cured with total abdominal hysterectomy and Chlorambucil Leukeren treatment.
This postoperative chemotherapy drug was among the slowest acting and least toxic of the alkylating agents well tolerated oral-dose drugs. By giving chemotherapy more often, at lower doses, it can prevent the regrowth of blood vessels that feed tumors. Depression of the immune system is slow and reversible, allowing it to regenerate and contribute to healing. A malfunctioning immune system can fail to stop the growth of cancer cells.
When caught at this earliest stage, ovarian cancer has a good prognosis. She went twenty-four years before experiencing any recurrent ovarian cancer. During the early 90's in Reading, Pa. This is supposed to be the most certain way of diagnosing ovarian cancer and assessing the extent of cancer spread metastasis.
For the most part, her group of oncologists relied almost entirely on the CA tumor marker a blood test done to assess the amount of an antibody that recognizes an antigen in ovarian tumor cells. The rate of "false positives" makes it inadequate for use "by itself" for screening of high-risk patients. It should be supplemented with transvaginal ultrasonography and a rectovaginal pelvic exam all done at the same time.
Metastatic Recurrence and Treatment: It was our family doctor that found her first metastatic recurrence to her diaphragm in not the medical oncologists at our local home town hospital. She was having dry coughing spells at first but then she began having a mucus discharge, which eventually was bloody. A chest xray and Cat Scan had shown a lesion inside her diaphragm. That recurrent ovarian cancer was surgically excised at Fox Chase Cancer Center.
It was a metastatic transdiaphragmatic tumor from the original ovarian cancer , with attachment to the lung and other midline structures of the chest. Parts of those structures were surgically resected the diaphragm is a common site for ovarian metastatic recurrence. It is very rare for ovarian cancer cells to metastisize to the CNS. In fact, up until there have been only 67 well documented cases in medical literature.
A multi-institutional study of ovarian cancer patients over 30 years identified only 32 cases while an autopsy study of ovarian cancer reported an incidence of 0. The surgeon at Fox Chase did not feel that further treatment with chemotherapy was indicated. However, the ideas of our local home town Medical Oncologists were different from the Thoracic Surgical Oncologist who excised the tumor from her diaphragm. My wife received postoperative chemotherapy by these medical oncologists, seven months after having that metastatic tumor surgically excised. She did not have any cancer tumor markers indicate any cancer within her system.
Some tumors send out microscopic outposts while most do not. However, medical oncologists cannot tell which ones do, so they want to give chemotherapy in nearly every case. The type of chemotherapy she received was the hit fast, hit hard type combination chemotherapy of Taxol with Carboplatin second-line chemotherapy. It is usually given in big doses, with breaks of several weeks between doses to let the body try to recover or else it can kill a patient.
Patients who develop recurrent ovarian cancer more than 6 months after first-line chemotherapy in my wife's case, 24 years , can experience another remission following treatment with the identical first-line chemotherapy that was previously used in her case, Chlorambucil. It has not been shown that platinum-based combination therapy is superior to single agent alkylator therapy. No substantial benefit has been found in giving ovarian cancer patients second-line chemotherapy.
Clinicians have found that the toxic effects of this treatment can cause a lower quality of life for these patients. In recent years the incidence of central nervous system CNS metastasis has increased. A NCI observational study in reported experience in their clinic where recurrent systemic disease occurred in all patients for which they received dose intense paclitaxel Taxol therapy.
Brain metastasis was the only site of disease recurrence, presenting with headache, dizziness, unsteady gait, nausea and vomiting. It was our family doctor that found her second metastatic recurrence to her cerebellum in not the medical oncologists at our local home town hospital. She was presenting with headache, dizziness, unsteady gait, nausea and vomiting. A large 3. The tumor was excised from her brain by a Neurosurgeon at Hershey Medical Center. Histologic features were consistent with metastatic papillary adenocarcinoma with extensive necrosis from the ovary. The treatment protocol recommended for brain metastases of large solitary tumors exceeding 2cm in diameter is surgical resection followed by 5 fractions of local radiation to the tumor bed.
At the same time, she should receive an MRI of the spine because of suspicions of either another tumor, on her spine or a herniated disc, causing her leg problems. However, the ideas of our local home town Radiation Oncologist were different from the Neurosurgeon who excised the tumor from her brain.
The Radiation Oncologist took it upon himself to give my wife 5 fractions of focal radiation to the local tumor bed, plus 20 fractions of Whole Brain Radiation over a 35 day period. The risk of neurotoxicity from Whole Brain Radiation is not insignificant and this approach is not indicated in all patients with a solitary brain metastases, particularly when platinum drugs lower the tolerance of the CNS to radiation. Whole Brain Radiation Therapy has been recognized to cause considerable permanent side effects in patients over 60 years of age.
My wife was 66 years of age while receiving Whole Brain Radiation Therapy. During radiation treatment, my wife received an Unenhanced MRI to the spine that showed a 1cm lesion. However, a Regular Bone Scan cannot distinguish what a lesion represents and cannot differentiate between a tumor, an infection or a fracture a Triple Phase Bone Scan may occasionally be helpful in determining benign from malignant lesions. Enhanced contrast agents increase the sensitivity, conspicuity and accuracy of an exam.
The agent most commonly used is Gadolinium. An Enhanced MRI was not performed and the Radiation Oncologist told us the lesion was nothing and not to worry about it. He also ignored my complaints about her having seizures during radiation therapy. Nine months later, my wife was admitted to our local home town hospital during the Memorial Day Weekend of , for a week of testing and evaluation for unexplained falls and light-headiness. After two weeks of failing to find out what was wrong with her, I took her by ambulance to Hershey Medical Center for proper medical treatment.
At Hershey Medical Center, we found out by a medical onocologist and a neurologist that she had Leptomeningeal Carcinomatous remember the undiagnose tumor of nine months prior, not further evaluated? An Enhanced MRI showed now three 3 metastatic tumors on her spine. Spinal metastases can grow into adjacent structures, such as into the meninges from the spine. The largest of these tumors grew into the meninges on the spine into the spinal fluid, hence Leptomeningeal Carcinomatous.
This was confirmed by a spinal tap. With the damage already done to her by our local home town hospital, the doctors at Hershey Medical in order to save her life or at least give her some time had to administer Intrathecal Methotrexate along with systemic radiation to the spine Admitted June 19, When both therapies are performed at the same time it doubles the theraputic dosages of each therapy increasing the neuro-toxic effects on the brain.
However, the cancer cells were eradicated completely from her central nervous system by this protocol. Ever since the second spinal tap at Hershey when methotrexate was already being administered , all of her spinal taps were negative for 10 consecutive times up until January 14, Adverse Side Effects of Treatments: My first experience with the side effects of combination chemotherapy and whole brain radiation was when she was at Hershey Medical Center in The doctors showed me the Enhanced Brain MRI from her previous year's cerebellum excision and the one done in The scans showed the progressive deteriation of her white matter white matter disease.
These reactions are due to changes in the white matter and death of brain tissue caused by radiation-damaged blood vessels. This clinical syndrome generally occurs 6 months to 2 years after radiation therapy. Symptoms include decreased intellect, memory impairment, confusion, personality changes and alteration of the normal function of the area irradiated all symptoms my wife had over the past year.
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